IGFBP3 (insulin like growth factor binding protein 3)

2003-02-01  

Identity

HGNC
LOCATION
7p12.3
LOCUSID
ALIAS
BP-53,IBP3
FUSION GENES

Other Information

Locus ID:

NCBI: 3486
MIM: 146732
HGNC: 5472
Ensembl: ENSG00000146674

Variants:

dbSNP: 3486
ClinVar: 3486
TCGA: ENSG00000146674
COSMIC: IGFBP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146674ENST00000275521P17936
ENSG00000146674ENST00000381083P17936
ENSG00000146674ENST00000381086B3KWK7
ENSG00000146674ENST00000417621H0Y5K2
ENSG00000146674ENST00000428530H0Y485
ENSG00000146674ENST00000448817C9JMX4
ENSG00000146674ENST00000613132A6XND0
ENSG00000146674ENST00000615754A6XND1

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
p53 signaling pathwayKEGGhsa04115
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Death Receptors and LigandsREACTOMER-HSA-6803211

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD20860465
PA445742Stomach NeoplasmsDiseaseClinicalAnnotationassociatedPD20860465
PA448871celecoxibChemicalPathwayassociated22336956

References

Pubmed IDYearTitleCitations
172938642007A common coding variant in CASP8 is associated with breast cancer risk.218
75661791995Induction of the growth inhibitor IGF-binding protein 3 by p53.175
152823252004EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.145
121221012002Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer.103
194779442009Unraveling insulin-like growth factor binding protein-3 actions in human disease.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
170187852006Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium.83
175677562007IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth.83
145618952003Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis.82
156818242005Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition.82

Citation

Dessen P

IGFBP3 (insulin like growth factor binding protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40932/igfbp3