IL10 (interleukin 10)

2003-08-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
CSIF,GVHDS,IL-10,IL10A,TGIF

Other Information

Locus ID:

NCBI: 3586
MIM: 124092
HGNC: 5962
Ensembl: ENSG00000136634

Variants:

dbSNP: 3586
ClinVar: 3586
TCGA: ENSG00000136634
COSMIC: IL10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136634ENST00000423557P22301
ENSG00000136634ENST00000423557Q6FGW4
ENSG00000136634ENST00000471071A0A286YEX3
ENSG00000136634ENST00000659065A0A590UK12
ENSG00000136634ENST00000659642A0A590UK12
ENSG00000136634ENST00000664374A0A590UK12

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
T cell receptor signaling pathwayKEGGko04660
AsthmaKEGGko05310
Autoimmune thyroid diseaseKEGGko05320
Systemic lupus erythematosusKEGGko05322
Allograft rejectionKEGGko05330
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
T cell receptor signaling pathwayKEGGhsa04660
AsthmaKEGGhsa05310
Autoimmune thyroid diseaseKEGGhsa05320
Systemic lupus erythematosusKEGGhsa05322
Allograft rejectionKEGGhsa05330
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
MalariaKEGGko05144
MalariaKEGGhsa05144
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
African trypanosomiasisKEGGko05143
African trypanosomiasisKEGGhsa05143
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
PertussisKEGGko05133
PertussisKEGGhsa05133
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
FoxO signaling pathwayKEGGhsa04068
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134850491TransplantationDiseaseClinicalAnnotationassociatedPK
PA164712462Antiinflammatory agents, non-steroidsChemicalClinicalAnnotationassociatedPD28750137
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPKPD18444945, 22094953
PA447230HIV InfectionsDiseaseClinicalAnnotationassociatedPD24819158
PA447247liver transplantationDiseaseClinicalAnnotationassociatedPD21359536
PA449167cyclosporineChemicalClinicalAnnotationassociatedPD18444945
PA449441efavirenzChemicalClinicalAnnotation, Literature, MultilinkAnnotationassociatedPD24819158
PA450566mycophenolate mofetilChemicalClinicalAnnotationassociatedPD18444945
PA451261rituximabChemicalMultilinkAnnotationassociated26384320
PA451365sirolimusChemicalClinicalAnnotationassociatedPK22094953
PA451578tacrolimusChemicalClinicalAnnotationassociatedPKPD21359536

References

Pubmed IDYearTitleCitations
194304802009Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.655
183878312008Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces.549
185839792008Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.395
196567762009DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific.337
198381952009A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.316
198381952009A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.316
224662872012Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.294
150707572004Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria.276
127308602003Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms.224
127308602003Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms.224

Citation

Dessen P

IL10 (interleukin 10)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40939/il10