IL16 (interleukin 16)

2003-11-01  

Identity

HGNC
LOCATION
15q25.1
LOCUSID
ALIAS
LCF,NIL16,PRIL16,prIL-16

Other Information

Locus ID:

NCBI: 3603
MIM: 603035
HGNC: 5980
Ensembl: ENSG00000172349

Variants:

dbSNP: 3603
ClinVar: 3603
TCGA: ENSG00000172349
COSMIC: IL16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172349ENST00000302987Q14005
ENSG00000172349ENST00000360547H3BT15
ENSG00000172349ENST00000394652Q14005
ENSG00000172349ENST00000394660Q14005
ENSG00000172349ENST00000558332H0YLH9
ENSG00000172349ENST00000558857H0YLB1
ENSG00000172349ENST00000559383H0YLL1
ENSG00000172349ENST00000560115H3BN12
ENSG00000172349ENST00000560241H0YKB7

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713176Platinum compoundsChemicalClinicalAnnotationassociatedPD27498158
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD27498158

References

Pubmed IDYearTitleCitations
182640962008Multiple loci identified in a genome-wide association study of prostate cancer.448
182640962008Multiple loci identified in a genome-wide association study of prostate cancer.448
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
210715402011Validation of genome-wide prostate cancer associations in men of African descent.51
208116262010Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.34
186768702008Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.31
190738782009The association of interleukin-16 polymorphisms with IL-16 serum levels and risk of colorectal and gastric cancer.28
190738782009The association of interleukin-16 polymorphisms with IL-16 serum levels and risk of colorectal and gastric cancer.28

Citation

Dessen P

IL16 (interleukin 16)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40944/il16