IL31 (interleukin 31)

2015-06-01  

Identity

HGNC
IL31
LOCATION
12q24.31
LOCUSID
386653
ALIAS
IL-31

Other Information

Locus ID:

NCBI: 386653
MIM: 609509
HGNC: 19372
Ensembl: ENSG00000204671

Variants:

dbSNP: 386653
ClinVar: 386653
TCGA: ENSG00000204671
COSMIC: IL31

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204671ENST00000377035Q6EBC2

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
201901402010Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells.52
189267622008Structures and biological functions of IL-31 and IL-31 receptors.51
261987702015Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology.40
221773282012IL-31 regulates differentiation and filaggrin expression in human organotypic skin models.37
236948082013Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation.30
192819092009The histamine H4 receptor is functionally expressed on T(H)2 cells.29
271529432016TSLP, IL-31, IL-33 and sST2 are new biomarkers in endophenotypic profiling of adult and childhood atopic dermatitis.21
225397922012Dendritic cells activated by IFN-γ/STAT1 express IL-31 receptor and release proinflammatory mediators upon IL-31 treatment.16
246670972014Distribution of IL-31 and its receptor expressing cells in skin of atopic dermatitis.15
273403182016Clinical Significance of Serum Interleukin-31 and Interleukin-33 Levels in Patients of Endometrial Cancer: A Case Control Study.12

Citation

Dessen P

IL31 (interleukin 31)

Atlas Genet Cytogenet Oncol Haematol. 2015-06-01

Online version: http://atlasgeneticsoncology.org/gene/55299/il31