IL6R (interleukin 6 receptor)

2003-08-01  

Identity

HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
CD126,HIES5,IL-1Ra,IL-6R,IL-6R-1,IL-6RA,IL6Q,IL6QTL,IL6RA,IL6RQ,gp80
FUSION GENES

Other Information

Locus ID:

NCBI: 3570
MIM: 147880
HGNC: 6019
Ensembl: ENSG00000160712

Variants:

dbSNP: 3570
ClinVar: 3570
TCGA: ENSG00000160712
COSMIC: IL6R

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160712ENST00000344086P08887
ENSG00000160712ENST00000368485P08887
ENSG00000160712ENST00000368485A0N0L5
ENSG00000160712ENST00000476006H0Y9B1
ENSG00000160712ENST00000512471D6R9R8
ENSG00000160712ENST00000515190H0Y949
ENSG00000160712ENST00000622330A0A087WTB5

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Hematopoietic cell lineageKEGGko04640
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Hematopoietic cell lineageKEGGhsa04640
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
HIF-1 signaling pathwayKEGGhsa04066
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 signalingREACTOMER-HSA-1059683
Signal TransductionREACTOMER-HSA-162582
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK1/MAPK3 signalingREACTOMER-HSA-5684996
RAF-independent MAPK1/3 activationREACTOMER-HSA-112409
MAPK3 (ERK1) activationREACTOMER-HSA-110056
MAPK1 (ERK2) activationREACTOMER-HSA-112411
Interleukin-6 family signalingREACTOMER-HSA-6783589
EGFR tyrosine kinase inhibitor resistanceKEGGko01521
EGFR tyrosine kinase inhibitor resistanceKEGGhsa01521
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA165292659tocilizumabChemicalClinicalAnnotationassociatedPD24978393, 27958380
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD24978393, 27958380

References

Pubmed IDYearTitleCitations
246424712014IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.201
224213392012Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.192
184649132008A genome-wide association study identifies protein quantitative trait loci (pQTLs).184
195674382009Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.180
128297852003Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex.169
187843732008Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease.136
219078642011Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.136
190887232009Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas.109
243462882014Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction.102
249864242014Interleukin-6 and its receptors: a highly regulated and dynamic system.102

Citation

Dessen P

IL6R (interleukin 6 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40963/il6r