JCHAIN (joining chain of multimeric IgA and IgM)

2014-11-01  

Identity

HGNC
LOCATION
4q13.3
LOCUSID
ALIAS
IGCJ,IGJ,JCH
FUSION GENES

Other Information

Locus ID:

NCBI: 3512
MIM: 147790
HGNC: 5713
Ensembl: ENSG00000132465

Variants:

dbSNP: 3512
ClinVar: 3512
TCGA: ENSG00000132465
COSMIC: JCHAIN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132465ENST00000254801P01591
ENSG00000132465ENST00000391614D6RHJ6
ENSG00000132465ENST00000470866C9JA05
ENSG00000132465ENST00000510437P01591
ENSG00000132465ENST00000510614D6RD17
ENSG00000132465ENST00000543780P01591

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging of heme from plasmaREACTOMER-HSA-2168880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
209474332011Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells.15
270445432016High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia.7

Citation

Dessen P

JCHAIN (joining chain of multimeric IgA and IgM)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64558/jchain