KAT7 (lysine acetyltransferase 7)

2011-08-01  

Identity

HGNC
KAT7
LOCATION
17q21.33
LOCUSID
11143
ALIAS
HBO1,HBOA,MYST2,ZC2HC7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11143
MIM: 609880
HGNC: 17016
Ensembl: ENSG00000136504

Variants:

dbSNP: 11143
ClinVar: 11143
TCGA: ENSG00000136504
COSMIC: KAT7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136504ENST00000259021O95251
ENSG00000136504ENST00000424009O95251
ENSG00000136504ENST00000435742E7EUP3
ENSG00000136504ENST00000454930O95251
ENSG00000136504ENST00000506533D6RFZ5
ENSG00000136504ENST00000509773O95251
ENSG00000136504ENST00000510819O95251

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
201290552010HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin.101
193725802009Genetic alterations and oncogenic pathways associated with breast cancer subtypes.90
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
164284612006Regulation of replication licensing by acetyltransferase Hbo1.71
120348782002Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo.63
188320672008HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1.62
240657672013Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity.48
119787942002The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing.45
182503002008Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing.45
221445822012Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation.38

Citation

Dessen P

KAT7 (lysine acetyltransferase 7)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52346/kat7