KCNIP2 (potassium voltage-gated channel interacting protein 2)

2014-11-01  

Identity

HGNC
LOCATION
10q24.32
LOCUSID
ALIAS
KCHIP2
FUSION GENES

Other Information

Locus ID:

NCBI: 30819
MIM: 604661
HGNC: 15522
Ensembl: ENSG00000120049

Variants:

dbSNP: 30819
ClinVar: 30819
TCGA: ENSG00000120049
COSMIC: KCNIP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120049ENST00000239117Q9NS61
ENSG00000120049ENST00000343195Q9NS61
ENSG00000120049ENST00000348850Q9NS61
ENSG00000120049ENST00000353068Q9NS61
ENSG00000120049ENST00000356640Q9NS61
ENSG00000120049ENST00000358038Q9NS61
ENSG00000120049ENST00000370046A6NFF4
ENSG00000120049ENST00000434163Q9NS61
ENSG00000120049ENST00000461105Q9NS61
ENSG00000120049ENST00000642874A0A2R8Y6D7

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 1 - inactivation of fast Na+ channelsREACTOMER-HSA-5576894

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
154988062004Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts.53
121359402002Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)?36
161778262005Transcriptional repressor DREAM regulates T-lymphocyte proliferation and cytokine gene expression.35
146238802004Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2.27
207097472010Co-assembly of Kv4 {alpha} subunits with K+ channel-interacting protein 2 stabilizes protein expression and promotes surface retention of channel complexes.24
189574402008Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating.21
206495992010Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2.18
204982292010The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner.13
129284442003Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide.12

Citation

Dessen P

KCNIP2 (potassium voltage-gated channel interacting protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64782/kcnip2