KCNK10 (potassium two pore domain channel subfamily K member 10)

2014-06-01 Affiliation

Identity

HGNC

KCNK10

LOCATION

14q31.3

LOCUSID

54207

ALIAS

K2p10.1,PPP1R97,TREK-2,TREK2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 54207
MIM: 605873
HGNC: 6273
Ensembl: ENSG00000100433

Variants:

dbSNP: 54207
ClinVar: 54207
TCGA: ENSG00000100433
COSMIC: KCNK10

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100433	ENST00000312350	P57789
ENSG00000100433	ENST00000319231	P57789
ENSG00000100433	ENST00000340700	P57789
ENSG00000100433	ENST00000556282	G3V5Y5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gastric acid secretion	KEGG	ko04971
Gastric acid secretion	KEGG	hsa04971
Neuronal System	REACTOME	R-HSA-112316
Potassium Channels	REACTOME	R-HSA-1296071
Tandem pore domain potassium channels	REACTOME	R-HSA-1296346
TWIK related potassium channel (TREK)	REACTOME	R-HSA-1299503
Muscle contraction	REACTOME	R-HSA-397014
Cardiac conduction	REACTOME	R-HSA-5576891
Phase 4 - resting membrane potential	REACTOME	R-HSA-5576886

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
25766236	2015	K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.	83
11897838	2002	Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2.	38
26332952	2015	How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.	19
25197053	2014	Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.	18
23479219	2013	Expression and effects of modulation of the K2P potassium channels TREK-1 (KCNK2) and TREK-2 (KCNK10) in the normal human ovary and epithelial ovarian cancer.	11
26381449	2015	The association of DNA methylation and brain volume in healthy individuals and schizophrenia patients.	11
17689202	2008	Recent advance and possible future in TREK-2: a two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment.	7
25982558	2015	Insights into the stimulatory mechanism of 2-aminoethoxydiphenyl borate on TREK-2 potassium channel.	6
21669980	2011	Alternative splicing determines mRNA translation initiation and function of human K(2P)10.1 K+ channels.	5
25168769	2014	Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation.	5

Citation

Dessen P

KCNK10 (potassium two pore domain channel subfamily K member 10)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53925/kcnk10