KIF18B (kinesin family member 18B)

2014-08-01  

Identity

HGNC
LOCATION
17q21.31
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 146909
MIM: 614570
HGNC: 27102
Ensembl: ENSG00000186185

Variants:

dbSNP: 146909
ClinVar: 146909
TCGA: ENSG00000186185
COSMIC: KIF18B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186185ENST00000587309Q86Y91
ENSG00000186185ENST00000590129A0A494BYR6
ENSG00000186185ENST00000593135Q86Y91

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
218203092011A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases.55
217376852011Kif18B interacts with EB1 and controls astral microtubule length during mitosis.43
252364632015Translating bioinformatics in oncology: guilt-by-profiling analysis and identification of KIF18B and CDCA3 as novel driver genes in carcinogenesis.23
206007032010Cell cycle-regulated expression and subcellular localization of a kinesin-8 member human KIF18B.15
296619122018Microtubule end tethering of a processive kinesin-8 motor Kif18b is required for spindle positioning.8
261505012015Biased Brownian motion as a mechanism to facilitate nanometer-scale exploration of the microtubule plus end by a kinesin-8.7
317594062019KIF18B as a regulator in microtubule movement accelerates tumor progression and triggers poor outcome in lung adenocarcinoma.1
316176522019Kinesin family member 18B: A contributor and facilitator in the proliferation and metastasis of cutaneous melanoma.0

Citation

Dessen P

KIF18B (kinesin family member 18B)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54411/kif18b