KIF20A (kinesin family member 20A)

2007-02-01  

Identity

HGNC
LOCATION
5q31.2
LOCUSID
ALIAS
MKLP2,RAB6KIFL
FUSION GENES

Other Information

Locus ID:

NCBI: 10112
MIM: 605664
HGNC: 9787
Ensembl: ENSG00000112984

Variants:

dbSNP: 10112
ClinVar: 10112
TCGA: ENSG00000112984
COSMIC: KIF20A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112984ENST00000394894O95235
ENSG00000112984ENST00000502338H0YAC9
ENSG00000112984ENST00000504621D6RBN1
ENSG00000112984ENST00000508792O95235
ENSG00000112984ENST00000513276D6R9E4

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic Telophase/CytokinesisREACTOMER-HSA-68884
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129392562003Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis.116
152630152004Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2.114
110600222000The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis.76
193032982009Cdk1 negatively regulates midzone localization of the mitotic kinesin Mklp2 and the chromosomal passenger complex.60
259619282016Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance.60
156652852005Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell.42
254992212014KIF20A-mediated RNA granule transport system promotes the invasiveness of pancreatic cancer cells.31
270360482016Aberrantly activated Gli2-KIF20A axis is crucial for growth of hepatocellular carcinoma and predicts poor prognosis.27
228879482012Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study.23
246568122014Cdk1 coordinates timely activation of MKlp2 kinesin with relocation of the chromosome passenger complex for cytokinesis.23

Citation

Dessen P

KIF20A (kinesin family member 20A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45523/kif20a