KRT15 (keratin 15)

2008-12-01  

Identity

HGNC
KRT15
LOCATION
17q21.2
LOCUSID
3866
ALIAS
CK15,K15,K1CO
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3866
MIM: 148030
HGNC: 6421
Ensembl: ENSG00000171346

Variants:

dbSNP: 3866
ClinVar: 3866
TCGA: ENSG00000171346
COSMIC: KRT15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171346ENST00000254043P19012
ENSG00000171346ENST00000393974A8MT21
ENSG00000171346ENST00000393976P19012
ENSG00000171346ENST00000458290C9JTG5
ENSG00000171346ENST00000470004K7EQK9
ENSG00000171346ENST00000497016K7EMX0

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
1000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
225384252012Angiogenesis potential of human limbal stromal niche cells.22
200500202009Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin.18
200500202009Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin.18
150601412004Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription.14
193833062007Identification of a subset of breast carcinomas characterized by expression of cytokeratin 15: relationship between CK15+ progenitor/amplified cells and pre-malignant lesions and invasive disease.11
226485502012Expression of basal cell keratin 15 and keratin 19 in oral squamous neoplasms represents diverse pathophysiologies.10
206563762010Endocrine controls of primary adult human stem cell biology: thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro.9
233984722013The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers.7
191622472009Hair follicle stem cells in the pathogenesis of the scarring process in cutaneous lupus erythematosus.5
242605552013Cytokeratin 15 marks basal epithelia in developing ureters and is upregulated in a subset of urothelial cell carcinomas.5

Citation

Dessen P

KRT15 (keratin 15)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50481/krt15