KRT17 (keratin 17)

2007-02-01  

Identity

HGNC
KRT17
LOCATION
17q21.2
LOCUSID
3872
ALIAS
39.1,CK-17,K17,PC,PC2,PCHC1

Other Information

Locus ID:

NCBI: 3872
MIM: 148069
HGNC: 6427
Ensembl: ENSG00000128422

Variants:

dbSNP: 3872
ClinVar: 3872
TCGA: ENSG00000128422
COSMIC: KRT17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128422ENST00000311208Q04695
ENSG00000128422ENST00000463128K7ESE1
ENSG00000128422ENST00000540235F5GWP8
ENSG00000128422ENST00000577817K7EPJ9
ENSG00000128422ENST00000648859A0A3B3IS58

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
1000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
124661142002Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome.134
261680142015Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes.44
197017592010Comparison between human fetal and adult skin.33
198822462010BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer.30
217961512011IL-17A upregulates keratin 17 expression in keratinocytes through STAT1- and STAT3-dependent mechanisms.29
257134162015Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes.22
226959332012Keratin 17 expression correlates with tumor progression and poor prognosis in gastric adenocarcinoma.20
228082662012The pro-inflammatory cytokine IL-22 up-regulates keratin 17 expression in keratinocytes via STAT3 and ERK1/2.19
261095592015Keratin-17 Promotes p27KIP1 Nuclear Export and Degradation and Offers Potential Prognostic Utility.19
240516972014Keratin 17 in premalignant and malignant squamous lesions of the cervix: proteomic discovery and immunohistochemical validation as a diagnostic and prognostic biomarker.18

Citation

Dessen P

KRT17 (keratin 17)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46323/krt17