LAPTM5 (lysosomal protein transmembrane 5)

2012-11-01  

Identity

HGNC
LOCATION
1p35.2
LOCUSID
ALIAS
CLAST6
FUSION GENES

Other Information

Locus ID:

NCBI: 7805
MIM: 601476
HGNC: 29612
Ensembl: ENSG00000162511

Variants:

dbSNP: 7805
ClinVar: 7805
TCGA: ENSG00000162511
COSMIC: LAPTM5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162511ENST00000294507Q13571
ENSG00000162511ENST00000294507Q5TBB8

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197870532009Lysosomal-associated protein multispanning transmembrane 5 gene (LAPTM5) is associated with spontaneous regression of neuroblastomas.15
128862552003Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma.7
220097532011HECT-type ubiquitin ligase ITCH targets lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) and prevents LAPTM5-mediated cell death.7
125279262003Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation: elevated expression in human B lymphomas.6
270586222016Down-regulation of LAPTM5 in human cancer cells.3
279226702017Downregulation of LAPTM5 suppresses cell proliferation and viability inducing cell cycle arrest at G0/G1 phase of bladder cancer cells.3
228800582012Lysosomal-associated transmembrane protein 5 (LAPTM5) is a molecular partner of CD1e.1
259985732015Expression and Polymorphisms of Lysosome-Associated Protein Transmembrane 5 (LAPTM5) in Patients with Systemic Lupus Erythematosus in a Chinese Population.0

Citation

Dessen P

LAPTM5 (lysosomal protein transmembrane 5)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/53018/laptm5