LCLAT1 (lysocardiolipin acyltransferase 1)

2014-08-01  

Identity

HGNC
LOCATION
2p23.1
LOCUSID
ALIAS
1AGPAT8,AGPAT8,ALCAT1,HSRG1849,LYCAT,UNQ1849
FUSION GENES

Other Information

Locus ID:

NCBI: 253558
MIM: 614241
HGNC: 26756
Ensembl: ENSG00000172954

Variants:

dbSNP: 253558
ClinVar: 253558
TCGA: ENSG00000172954
COSMIC: LCLAT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172954ENST00000309052Q6UWP7
ENSG00000172954ENST00000319406Q6UWP7
ENSG00000172954ENST00000379509Q6UWP7
ENSG00000172954ENST00000465200C9JMW2
ENSG00000172954ENST00000465538C9JA02
ENSG00000172954ENST00000466477C9JXY8
ENSG00000172954ENST00000476038C9K0C3
ENSG00000172954ENST00000476535C9JUV9
ENSG00000172954ENST00000478015F8WEY2
ENSG00000172954ENST00000488144C9J5S5
ENSG00000172954ENST00000497423C9J6F4

Expression (GTEx)

0
1
2
3
4
5
6
7

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerophospholipid metabolismKEGGko00564
Glycerolipid metabolismKEGGhsa00561
Glycerophospholipid metabolismKEGGhsa00564
Metabolic pathwaysKEGGhsa01100
Triacylglycerol biosynthesisKEGGhsa_M00089
Triacylglycerol biosynthesisKEGGM00089
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PAREACTOMER-HSA-1483166
Acyl chain remodeling of CLREACTOMER-HSA-1482798

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
287510232017Lysocardiolipin acyltransferase regulates TGF-β mediated lung fibroblast differentiation.6
190750292009The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids.0
247797082014The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis.0

Citation

Dessen P

LCLAT1 (lysocardiolipin acyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54419/lclat1