LMOD1 (leiomodin 1)

2016-08-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
1D,64kD,D1,SM-LMOD,SMLMOD
FUSION GENES

Other Information

Locus ID:

NCBI: 25802
MIM: 602715
HGNC: 6647
Ensembl: ENSG00000163431

Variants:

dbSNP: 25802
ClinVar: 25802
TCGA: ENSG00000163431
COSMIC: LMOD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163431ENST00000367288P29536
ENSG00000163431ENST00000616739Q9BV00

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Muscle contractionREACTOMER-HSA-397014
Smooth Muscle ContractionREACTOMER-HSA-445355

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
113186032001Leiomodins: larger members of the tropomodulin (Tmod) gene family.60
221570092012Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cells.37
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
166331402006Risperidone-related weight gain: genetic and nongenetic predictors.26
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
113507612001Leiomodin and tropomodulin in smooth muscle.20
282928962017Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice.14
274705162016Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.13
196251762009PTEN identified as important risk factor of chronic obstructive pulmonary disease.12

Citation

Dessen P

LMOD1 (leiomodin 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55867/lmod1