LRRTM3 (leucine rich repeat transmembrane neuronal 3)

2014-11-01 Affiliation

Identity

HGNC

LRRTM3

LOCATION

10q21.3

LOCUSID

347731

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 347731
MIM: 610869
HGNC: 19410
Ensembl: ENSG00000198739

Variants:

dbSNP: 347731
ClinVar: 347731
TCGA: ENSG00000198739
COSMIC: LRRTM3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000198739	ENST00000361320	Q86VH5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuronal System	REACTOME	R-HSA-112316
Protein-protein interactions at synapses	REACTOME	R-HSA-6794362
Interactions of neurexins and neuroligins at synapses	REACTOME	R-HSA-6794361

References

Pubmed ID	Year	Title	Citations
20678249	2010	Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry.	21
19105203	2009	An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.	16
19105203	2009	An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.	16
21598020	2011	Alpha T-catenin (CTNNA3): a gene in the hand is worth two in the nest.	6
23750206	2013	LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).	4
22710909	2012	LRRTM3 is dispensable for amyloid-β production in mice.	2
17098871	2006	LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.	0
22393166	2012	Effect of genetic variation in LRRTM3 on risk of Alzheimer disease.	0
24463050	2014	Association of LRRTM3 polymorphisms with late-onset Alzheimer's disease in Han Chinese.	0

Citation

Dessen P

LRRTM3 (leucine rich repeat transmembrane neuronal 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68673/lrrtm3