MAD2L1BP (MAD2L1 binding protein)

2007-12-01 Affiliation

Identity

HGNC

MAD2L1BP

LOCATION

6p21.1

LOCUSID

9587

ALIAS

CMT2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9587
MIM: 618136
HGNC: 21059
Ensembl: ENSG00000124688

Variants:

dbSNP: 9587
ClinVar: 9587
TCGA: ENSG00000124688
COSMIC: MAD2L1BP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000124688	ENST00000372171	Q15013
ENSG00000124688	ENST00000451025	Q15013

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
15257285	2004	Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint.	98
18022368	2007	p31comet blocks Mad2 activation through structural mimicry.	97
22100920	2011	p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit.	70
21300909	2011	p31comet Promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process.	59
25092294	2014	Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31(comet).	46
21772247	2011	Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint.	40
21937719	2011	Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31(comet).	32
21965286	2011	p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment.	29
26324890	2015	Mode of interaction of TRIP13 AAA-ATPase with the Mad2-binding protein p31comet and with mitotic checkpoint complexes.	22
22544748	2012	Depletion of p31comet protein promotes sensitivity to antimitotic drugs.	15

Citation

Dessen P

MAD2L1BP (MAD2L1 binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49962/mad2l1bp