MAL2 (mal, T cell differentiation protein 2)

2007-12-01  

Identity

HGNC
MAL2
LOCATION
8q24.12
LOCUSID
114569
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 114569
MIM: 609684
HGNC: 13634
Ensembl: ENSG00000147676

Variants:

dbSNP: 114569
ClinVar: 114569
TCGA: ENSG00000147676
COSMIC: MAL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147676ENST00000522112A0A087WZL1
ENSG00000147676ENST00000531508A0A087WZL1
ENSG00000147676ENST00000534619A0A087WZL1
ENSG00000147676ENST00000614891Q969L2
ENSG00000147676ENST00000614891A0A024R9E4

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
123702462002MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells.38
171458112006Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes.22
208464532010MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome.12
196835242009Characterization of the MAL2-positive compartment in oligodendrocytes.11
166209672006Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations.9
191759402009Mucin 1 (MUC1) is a novel partner for MAL2 in breast carcinoma cells.9
215730572011Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG.9
250845252014Serine/threonine kinase 16 and MAL2 regulate constitutive secretion of soluble cargo in hepatic cells.8
145761882004Expression and distribution of MAL2, an essential element of the machinery for basolateral-to-apical transcytosis, in human thyroid epithelial cells.7
285626872017The four-transmembrane protein MAL2 and tumor protein D52 (TPD52) are highly expressed in colorectal cancer and correlated with poor prognosis.5

Citation

Dessen P

MAL2 (mal, T cell differentiation protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49874/mal2