MAP3K10 (mitogen-activated protein kinase kinase kinase 10)

2003-02-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
MEKK10,MLK2,MST
FUSION GENES

Other Information

Locus ID:

NCBI: 4294
MIM: 600137
HGNC: 6849
Ensembl: ENSG00000130758

Variants:

dbSNP: 4294
ClinVar: 4294
TCGA: ENSG00000130758
COSMIC: MAP3K10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130758ENST00000253055Q02779
ENSG00000130758ENST00000593502M0R365
ENSG00000130758ENST00000594951M0R0A7
ENSG00000130758ENST00000597986M0R1J8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MAPK (JNK) signalingKEGGhsa_M00688
MAPK (p38) signalingKEGGhsa_M00689
MAPK (JNK) signalingKEGGM00688
MAPK (p38) signalingKEGGM00689

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
219799192011TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.43
219799192011TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.43
175847362007Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release.17
237603662013The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1.12
231784522013MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2.8
289477952017Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control.8
121052002002Mixed lineage kinase 2 interacts with clathrin and influences clathrin-coated vesicle trafficking.5
198016492009Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways.5
205969612010microRNA-181b targets MLK2 in HL-60 cells.5
216784192012Identification of RUNX3 as a component of the MST/Hpo signaling pathway.5

Citation

Dessen P

MAP3K10 (mitogen-activated protein kinase kinase kinase 10)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41276/map3k10