MAT2A (methionine adenosyltransferase 2A)

2007-02-01  

Identity

HGNC
LOCATION
2p11.2
LOCUSID
ALIAS
MATA2,MATII,SAMS2
FUSION GENES

Other Information

Locus ID:

NCBI: 4144
MIM: 601468
HGNC: 6904
Ensembl: ENSG00000168906

Variants:

dbSNP: 4144
ClinVar: 4144
TCGA: ENSG00000168906
COSMIC: MAT2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168906ENST00000306434P31153
ENSG00000168906ENST00000306434A0A140VJP5
ENSG00000168906ENST00000409017P31153

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Pathways

PathwaySourceExternal ID
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Methionine degradationKEGGhsa_M00035
Methionine salvage pathwayKEGGhsa_M00034
Methionine salvage pathwayKEGGM00034
Methionine degradationKEGGM00035
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
MethylationREACTOMER-HSA-156581

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
285257532017The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.119
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
213625512011Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein.57
270684732016MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis.53
176311432007Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells.45
214601022011Hypoxia induces genomic DNA demethylation through the activation of HIF-1α and transcriptional upregulation of MAT2A in hepatoma cells.45
180417132008Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta.39
292623162017S-Adenosylmethionine Synthesis Is Regulated by Selective N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1.38
126718912003Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma.35
126602482003L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine.30

Citation

Dessen P

MAT2A (methionine adenosyltransferase 2A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43637/mat2a