MED19 (mediator complex subunit 19)

2003-06-01  

Identity

HGNC
LOCATION
11q12.1
LOCUSID
ALIAS
DT2P1G7,LCMR1,MED19AS
FUSION GENES

Other Information

Locus ID:

NCBI: 219541
MIM: 612385
HGNC: 29600
Ensembl: ENSG00000156603

Variants:

dbSNP: 219541
ClinVar: 219541
TCGA: ENSG00000156603
COSMIC: MED19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156603ENST00000337672A0JLT2
ENSG00000156603ENST00000431606J3KR33
ENSG00000156603ENST00000645681A0JLT2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD32451486
PA448073ethanolChemicalClinicalAnnotationassociatedPD32451486

References

Pubmed IDYearTitleCitations
190499682009MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression.29
208906032011Lentivirus-mediated inhibition of Med19 suppresses growth of breast cancer cells in vitro.10
214780382012Expression of Med19 in bladder cancer tissues and its role on bladder cancer cell growth.10
278118582016The FOXD3/miR-214/MED19 axis suppresses tumour growth and metastasis in human colorectal cancer.10
232764572013Med19 promotes bone metastasis and invasiveness of bladder urothelial carcinoma via bone morphogenetic protein 2.9
215199212011MED19 promotes proliferation and tumorigenesis of lung cancer.8
213728272011The role of Med19 in the proliferation and tumorigenesis of human hepatocellular carcinoma cells.6
225651892012Med19 promotes gastric cancer progression and cellular growth.6
218711802011Suppression of MED19 expression by shRNA induces inhibition of cell proliferation and tumorigenesis in human prostate cancer cells.5
273750182017A large-scale RNAi screen identifies LCMR1 as a critical regulator of Tspan8-mediated melanoma invasion.4

Citation

Dessen P

MED19 (mediator complex subunit 19)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41131/med19