MED22 (mediator complex subunit 22)

2012-07-01  

Identity

HGNC
LOCATION
9q34.2
LOCUSID
ALIAS
MED24,SRB6,SURF5,surf-5
FUSION GENES

Other Information

Locus ID:

NCBI: 6837
MIM: 185641
HGNC: 11477
Ensembl: ENSG00000148297

Variants:

dbSNP: 6837
ClinVar: 6837
TCGA: ENSG00000148297
COSMIC: MED22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148297ENST00000343730Q15528
ENSG00000148297ENST00000343730A0A024R8C5
ENSG00000148297ENST00000371999Q5T8T7
ENSG00000148297ENST00000446777Q5T8T8
ENSG00000148297ENST00000457204E9PGW7
ENSG00000148297ENST00000494177E7EN96
ENSG00000148297ENST00000610672Q15528
ENSG00000148297ENST00000610672A0A024R8C5
ENSG00000148297ENST00000610888Q15528
ENSG00000148297ENST00000614493Q15528

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
223314692012Mediator subunits MED1 and MED24 cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells.18
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
85864151995Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene.2
118910582002The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts.2

Citation

Dessen P

MED22 (mediator complex subunit 22)

Atlas Genet Cytogenet Oncol Haematol. 2012-07-01

Online version: http://atlasgeneticsoncology.org/gene/52772/med22