MED25 (mediator complex subunit 25)

2011-03-01  

Identity

HGNC
MED25
LOCATION
19q13.33
LOCUSID
81857
ALIAS
ACID1,ARC92,BVSYS,CMT2B2,P78,PTOV2,TCBAP0758
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 81857
MIM: 610197
HGNC: 28845
Ensembl: ENSG00000104973

Variants:

dbSNP: 81857
ClinVar: 81857
TCGA: ENSG00000104973
COSMIC: MED25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104973ENST00000312865Q71SY5
ENSG00000104973ENST00000538643Q71SY5
ENSG00000104973ENST00000593767M0QZQ2
ENSG00000104973ENST00000595185M0QYR4
ENSG00000104973ENST00000612791A0A087WW16
ENSG00000104973ENST00000612854A0A087WYW9
ENSG00000104973ENST00000617849B9TX31
ENSG00000104973ENST00000618715B9TX31
ENSG00000104973ENST00000620467B9TX33
ENSG00000104973ENST00000622402A0A087WTR5

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
149830112004The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator.62
214277222011Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25.52
213789652011Structure and VP16 binding of the Mediator Med25 activator interaction domain.40
213789632011Structure of the VP16 transactivator target in the Mediator.38
176416892007MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation.35
211351262011Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver.28
192905562009Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models.23
200898042010Kaposi's sarcoma-associated herpesvirus Lana-1 is a major activator of the serum response element and mitogen-activated protein kinase pathways via interactions with the Mediator complex.23
209742562011NMR structure of the human Mediator MED25 ACID domain.15
211109512011PTOV1 antagonizes MED25 in RAR transcriptional activation.10

Citation

Dessen P

MED25 (mediator complex subunit 25)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52109/med25