METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit)

2017-08-01  

Identity

HGNC
METTL3
LOCATION
14q11.2
LOCUSID
56339
ALIAS
IME4,M6A,MT-A70,Spo8,hMETTL3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56339
MIM: 612472
HGNC: 17563
Ensembl: ENSG00000165819

Variants:

dbSNP: 56339
ClinVar: 56339
TCGA: ENSG00000165819
COSMIC: METTL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165819ENST00000298717Q86U44
ENSG00000165819ENST00000377543A0A0G2JH39
ENSG00000165819ENST00000537163B4E349
ENSG00000165819ENST00000539760H0YFV6
ENSG00000165819ENST00000543235B4DTN4
ENSG00000165819ENST00000544248F5H6D8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203

References

Pubmed IDYearTitleCitations
254568342014m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.252
242096182013RNA-methylation-dependent RNA processing controls the speed of the circadian clock.244
271177022016The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.236
289209582017The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.170
291861252017Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control.138
273733372016Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.129
272811942016Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex.125
289912272018Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance.82
276277982016Structural insights into the molecular mechanism of the m(6)A writer complex.81
291748032018HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g.65

Citation

Dessen P

METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57050/mettl3