MGLL (monoglyceride lipase)

2010-02-01  

Identity

HGNC
LOCATION
3q21.3
LOCUSID
ALIAS
HU-K5,HUK5,MAGL,MGL
FUSION GENES

Other Information

Locus ID:

NCBI: 11343
MIM: 609699
HGNC: 17038
Ensembl: ENSG00000074416

Variants:

dbSNP: 11343
ClinVar: 11343
TCGA: ENSG00000074416
COSMIC: MGLL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074416ENST00000265052A0A0C4DFN3
ENSG00000074416ENST00000398101E7EWX8
ENSG00000074416ENST00000398104Q99685
ENSG00000074416ENST00000434178Q99685
ENSG00000074416ENST00000453507Q99685
ENSG00000074416ENST00000484451H7C599
ENSG00000074416ENST00000487473H7C5K5
ENSG00000074416ENST00000493611C9J8Q3
ENSG00000074416ENST00000494830C9JAM4
ENSG00000074416ENST00000496306H7C4E0
ENSG00000074416ENST00000648300A0A3B3ITT3

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerolipid metabolismKEGGhsa00561
Metabolic pathwaysKEGGhsa01100
Acylglycerol degradationKEGGhsa_M00098
Acylglycerol degradationKEGGM00098
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Regulation of lipolysis in adipocytesKEGGhsa04923
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Arachidonate production from DAGREACTOMER-HSA-426048
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysisREACTOMER-HSA-163560
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Acyl chain remodeling of DAG and TAGREACTOMER-HSA-1482883

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200793332010Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis.305
218020062011Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer.97
208554652010Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
199572602010Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling.50
209762462010A covering method for detecting genetic associations between rare variants and common phenotypes.50
199623852010Structural basis for human monoglyceride lipase inhibition.47
187217562008Covalent inhibitors of human monoacylglycerol lipase: ligand-assisted characterization of the catalytic site by mass spectrometry and mutational analysis.34
215431552011Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer.32
213088482011Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution.27

Citation

Dessen P

MGLL (monoglyceride lipase)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51356/mgll