MRPS18B (mitochondrial ribosomal protein S18B)

2014-08-01  

Identity

HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
C6orf14,HSPC183,HumanS18a,MRP-S18-2,MRPS18-2,PTD017,S18amt
FUSION GENES

Other Information

Locus ID:

NCBI: 28973
MIM: 611982
HGNC: 14516
Ensembl: ENSG00000204568

Variants:

dbSNP: 28973
ClinVar: 28973
TCGA: ENSG00000204568
COSMIC: MRPS18B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204568ENST00000259873Q9Y676
ENSG00000204568ENST00000259873B0S7P4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial translationREACTOMER-HSA-5368287
Mitochondrial translation initiationREACTOMER-HSA-5368286
Mitochondrial translation elongationREACTOMER-HSA-5389840
Mitochondrial translation terminationREACTOMER-HSA-5419276

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
183912032008EBV-encoded EBNA-6 binds and targets MRS18-2 to the nucleus, resulting in the disruption of pRb-E2F1 complexes.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
260237992015Mitochondrial ribosomal protein S18-2 evokes chromosomal instability and transforms primary rat skin fibroblasts.10
269591192016Mitochondrial ribosomal protein S18-2 is highly expressed in endometrial cancers along with free E2F1.4
293964842018The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells.2
274893522016S18 family of mitochondrial ribosomal proteins: evolutionary history and Gly132 polymorphism in colon carcinoma.1
283618602017Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development?1
305937502018Overexpression of the mitochondrial ribosomal protein S18-2 in the invasive breast carcinomas.0

Citation

Dessen P

MRPS18B (mitochondrial ribosomal protein S18B)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54472/mrps18b