NKD1 (NKD inhibitor of WNT signaling pathway 1)

2010-05-01  

Identity

HGNC
LOCATION
16q12.1
LOCUSID
ALIAS
Naked1
FUSION GENES

Other Information

Locus ID:

NCBI: 85407
MIM: 607851
HGNC: 17045
Ensembl: ENSG00000140807

Variants:

dbSNP: 85407
ClinVar: 85407
TCGA: ENSG00000140807
COSMIC: NKD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140807ENST00000268459Q969G9

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199567162009Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling.17
281071932017MicroRNA-744 promotes prostate cancer progression through aberrantly activating Wnt/β-catenin signaling.14
282920202017Long non-coding RNA HNF1A-AS1 promotes hepatocellular carcinoma cell proliferation by repressing NKD1 and P21 expression.12
215999232011Down-regulation of NKD1 increases the invasive potential of non-small-cell lung cancer and correlates with a poor prognosis.9
280323802017MicroRNA-195-5p suppresses osteosarcoma cell proliferation and invasion by suppressing naked cuticle homolog 1.9
272311342016The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells.7
260975892015NKD1 down-regulation is associated with poor prognosis in breast invasive ductal carcinoma.3
284434692017Low NKD1 expression predicts adverse prognosis in cytogenetically normal acute myeloid leukemia.3
275076142016NKD1 correlates with a poor prognosis and inhibits cell proliferation by inducing p53 expression in hepatocellular carcinoma.1
291155012018Downregulation of NKD1 in human osteosarcoma and its clinical significance.0

Citation

Dessen P

NKD1 (NKD inhibitor of WNT signaling pathway 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51466/nkd1