NLRC5 (NLR family CARD domain containing 5)

2016-10-01 Affiliation

Identity

HGNC

NLRC5

LOCATION

16q13

LOCUSID

84166

ALIAS

CLR16.1,NOD27,NOD4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 84166
MIM: 613537
HGNC: 29933
Ensembl: ENSG00000140853

Variants:

dbSNP: 84166
ClinVar: 84166
TCGA: ENSG00000140853
COSMIC: NLRC5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000140853	ENST00000262510	Q86WI3
ENSG00000140853	ENST00000399221	H0YFT3
ENSG00000140853	ENST00000436936	Q86WI3
ENSG00000140853	ENST00000537056	H0YF88
ENSG00000140853	ENST00000538059	F5GYP0
ENSG00000140853	ENST00000538110	H0YG32
ENSG00000140853	ENST00000538453	H0YGT6
ENSG00000140853	ENST00000538805	H0YGE2
ENSG00000140853	ENST00000539144	Q86WI3
ENSG00000140853	ENST00000539881	Q86WI3
ENSG00000140853	ENST00000540182	H0YFG4
ENSG00000140853	ENST00000543030	H0YFT1
ENSG00000140853	ENST00000544641	F5H274
ENSG00000140853	ENST00000545081	H0YGM1
ENSG00000140853	ENST00000545349	H0YGV6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	REACTOME	R-HSA-168928
Negative regulators of RIG-I/MDA5 signaling	REACTOME	R-HSA-936440

References

Pubmed ID	Year	Title	Citations
20434986	2010	NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.	141
20639463	2010	NLR family member NLRC5 is a transcriptional regulator of MHC class I genes.	107
20610642	2010	NLRC5 limits the activation of inflammatory pathways.	74
21191067	2011	Cutting edge: NLRC5-dependent activation of the inflammasome.	71
20061403	2010	The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses.	66
23815151	2013	Rhinovirus-induced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells.	54
20538593	2010	A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses.	52
22412192	2012	NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells.	44
22490869	2012	NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression.	42
27162338	2016	NLRC5/MHC class I transactivator is a target for immune evasion in cancer.	36

Citation

Dessen P

NLRC5 (NLR family CARD domain containing 5)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56616/nlrc5