NOSIP (nitric oxide synthase interacting protein)

2014-11-01  

Identity

HGNC
NOSIP
LOCATION
19q13.33
LOCUSID
51070
ALIAS
CGI-25

Other Information

Locus ID:

NCBI: 51070
MIM: 616759
HGNC: 17946
Ensembl: ENSG00000142546

Variants:

dbSNP: 51070
ClinVar: 51070
TCGA: ENSG00000142546
COSMIC: NOSIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142546ENST00000339093A0A075B6F9
ENSG00000142546ENST00000594932M0R1T7
ENSG00000142546ENST00000596358Q9Y314
ENSG00000142546ENST00000598296M0R1K2
ENSG00000142546ENST00000598544M0QX85
ENSG00000142546ENST00000599537M0R3B2
ENSG00000142546ENST00000600019M0R1T7
ENSG00000142546ENST00000601015A0A075B797

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of nitric oxideREACTOMER-HSA-202131
eNOS activation and regulationREACTOMER-HSA-203765
NOSIP mediated eNOS traffickingREACTOMER-HSA-203754

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
111498952001NOSIP, a novel modulator of endothelial nitric oxide synthase activity.48
161358132005Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton.12
281966632017NOS-interacting protein (NOSIP) is increased in the colon of patients with Hirschsprungs's disease.0

Citation

Dessen P

NOSIP (nitric oxide synthase interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70909/nosip