NPTX2 (neuronal pentraxin 2)

2008-01-01 Affiliation

Identity

HGNC

NPTX2

LOCATION

7q22.1

LOCUSID

4885

ALIAS

NARP,NP-II,NP2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4885
MIM: 600750
HGNC: 7953
Ensembl: ENSG00000106236

Variants:

dbSNP: 4885
ClinVar: 4885
TCGA: ENSG00000106236
COSMIC: NPTX2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000106236	ENST00000265634	P47972

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

cerebral cortex

cerebellum

hippocampus

caudate

thyroid gland

parathyroid gland

adrenal gland

pituitary gland

nasopharynx

bronchus

lung

oral mucosa

salivary gland

esophagus

stomach 1

stomach 2

duodenum

small intestine

colon

rectum

liver

gallbladder

pancreas

kidney

urinary bladder

testis

epididymis

seminal vesicle

prostate

vagina

ovary

fallopian tube

endometrium 1

endometrium 2

cervix, uterine

placenta

breast

heart muscle

smooth muscle

skeletal muscle

soft tissue 1

soft tissue 2

adipose tissue

skin 1

skin 2

appendix

spleen

lymph node

tonsil

bone marrow

References

Pubmed ID	Year	Title	Citations
23889936	2013	Obligatory role for the immediate early gene NARP in critical period plasticity.	48
24962026	2014	Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4.	39
24078801	2013	A DNA methylation prognostic signature of glioblastoma: identification of NPTX2-PTEN-NF-κB nexus.	29
17987278	2008	Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies.	24
28440221	2017	NPTX2 and cognitive dysfunction in Alzheimer's Disease.	20
19058789	2009	A common variant in DRD3 receptor is associated with autism spectrum disorder.	19
23624749	2013	Promoter methylation of AREG, HOXA11, hMLH1, NDRG2, NPTX2 and Tes genes in glioblastoma.	15
19667215	2009	Human NARP mitochondrial mutation metabolism corrected with alpha-ketoglutarate/aspartate: a potential new therapy.	12
27444967	2016	Neuronal Pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimer's disease spectrum.	12
21778928	2012	The role of quantitative NPTX2 hypermethylation as a novel serum diagnostic marker in pancreatic cancer.	11

Citation

Dessen P

NPTX2 (neuronal pentraxin 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49994/nptx2