NR2E1 (nuclear receptor subfamily 2 group E member 1)

2010-04-01  

Identity

HGNC
NR2E1
LOCATION
6q21
LOCUSID
7101
ALIAS
TLL,TLX,XTLL

Other Information

Locus ID:

NCBI: 7101
MIM: 603849
HGNC: 7973
Ensembl: ENSG00000112333

Variants:

dbSNP: 7101
ClinVar: 7101
TCGA: ENSG00000112333
COSMIC: NR2E1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112333ENST00000368983Q9Y466
ENSG00000112333ENST00000368986Q9Y466
ENSG00000112333ENST00000368986B6ZGT9
ENSG00000112333ENST00000426403A6PVF6

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
213680522011MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors.137
178730652007Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation.103
203603852010The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation.60
183910132008Transrepressive function of TLX requires the histone demethylase LSD1.52
219572442011Activation of postnatal neural stem cells requires nuclear receptor TLX.37
269658272016The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model.25
208147492010The neural stem cell fate determinant TLX promotes tumorigenesis and genesis of cells resembling glioma stem cells.21
160006152005Pathological aggression in "fierce" mice corrected by human nuclear receptor 2E1.19
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
230280432012The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche.17

Citation

Dessen P

NR2E1 (nuclear receptor subfamily 2 group E member 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-04-01

Online version: http://atlasgeneticsoncology.org/gene/51422/nr2e1