NRG2 (neuregulin 2)

2008-03-01 Affiliation

Identity

HGNC

NRG2

LOCATION

5q31.2

LOCUSID

9542

ALIAS

DON1,HRG2,NTAK

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9542
MIM: 603818
HGNC: 7998
Ensembl: ENSG00000158458

Variants:

dbSNP: 9542
ClinVar: 9542
TCGA: ENSG00000158458
COSMIC: NRG2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000158458	ENST00000289409	O14511
ENSG00000158458	ENST00000289422	O14511
ENSG00000158458	ENST00000340391	O14511
ENSG00000158458	ENST00000358522	O14511
ENSG00000158458	ENST00000361474	O14511
ENSG00000158458	ENST00000378238	O14511
ENSG00000158458	ENST00000541337	F5GZS7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
ErbB signaling pathway	KEGG	ko04012
ErbB signaling pathway	KEGG	hsa04012
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
PI3K/AKT Signaling in Cancer	REACTOME	R-HSA-2219528
Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME	R-HSA-2219530
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
PIP3 activates AKT signaling	REACTOME	R-HSA-1257604
Negative regulation of the PI3K/AKT network	REACTOME	R-HSA-199418
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
GAB1 signalosome	REACTOME	R-HSA-180292
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
PI3K/AKT activation	REACTOME	R-HSA-198203
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
Signaling by ERBB2	REACTOME	R-HSA-1227986
SHC1 events in ERBB2 signaling	REACTOME	R-HSA-1250196
GRB2 events in ERBB2 signaling	REACTOME	R-HSA-1963640
PI3K events in ERBB2 signaling	REACTOME	R-HSA-1963642
GRB7 events in ERBB2 signaling	REACTOME	R-HSA-1306955
Downregulation of ERBB2:ERBB3 signaling	REACTOME	R-HSA-1358803
Signaling by ERBB4	REACTOME	R-HSA-1236394
SHC1 events in ERBB4 signaling	REACTOME	R-HSA-1250347
PI3K events in ERBB4 signaling	REACTOME	R-HSA-1250342
Nuclear signaling by ERBB4	REACTOME	R-HSA-1251985
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME	R-HSA-6811558
ERBB2 Regulates Cell Motility	REACTOME	R-HSA-6785631
ERBB2 Activates PTK6 Signaling	REACTOME	R-HSA-8847993
Signaling by PTK6	REACTOME	R-HSA-8848021
EGFR tyrosine kinase inhibitor resistance	KEGG	ko01521
EGFR tyrosine kinase inhibitor resistance	KEGG	hsa01521
RET signaling	REACTOME	R-HSA-8853659
Downregulation of ERBB2 signaling	REACTOME	R-HSA-8863795

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10040	cetuximab	Chemical	Pathway	associated
PA162373091	panitumumab	Chemical	Pathway	associated

References

Pubmed ID	Year	Title	Citations
17962208	2008	ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis.	46
17598910	2007	Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia.	37
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34
17563728	2007	Fine mapping of new glaucoma locus GLC1M and exclusion of neuregulin 2 as the causative gene.	10
17563728	2007	Fine mapping of new glaucoma locus GLC1M and exclusion of neuregulin 2 as the causative gene.	10
17945187	2007	Inter-conversion of neuregulin2 full and partial agonists for ErbB4.	10
14722120	2004	The N-terminal region of NTAK/neuregulin-2 isoforms has an inhibitory activity on angiogenesis.	7
15961242	2005	Stimulation of acetylcholine receptor transcription by neuregulin-2 requires an N-box response element and is regulated by alternative splicing.	4
27345716	2016	Identification of Neuregulin-2 as a novel stress granule component.	2

Citation

Dessen P

NRG2 (neuregulin 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50050/nrg2