NUCKS1 (nuclear casein kinase and cyclin dependent kinase substrate 1)

2010-07-01  

Identity

HGNC
NUCKS1
LOCATION
1q32.1
LOCUSID
64710
ALIAS
JC7,NUCKS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64710
MIM: 611912
HGNC: 29923
Ensembl: ENSG00000069275

Variants:

dbSNP: 64710
ClinVar: 64710
TCGA: ENSG00000069275
COSMIC: NUCKS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000069275ENST00000367142Q9H1E3

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199155752009Genome-wide association study reveals genetic risk underlying Parkinson's disease.697
199155762009Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.471
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
206834862010Genetic variability at the PARK16 locus.29
230657112013Identification of NUCKS1 as a colorectal cancer prognostic marker through integrated expression and copy number analysis.23
269890742016MicroRNA-137 inhibits tumor growth and sensitizes chemosensitivity to paclitaxel and cisplatin in lung cancer.21
263233182015NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.16
184913812008Constitutive and dynamic phosphorylation and acetylation sites on NUCKS, a hypermodified nuclear protein, studied by quantitative proteomics.13
200690582009Immunohistochemical and proteomic evaluation of nuclear ubiquitous casein and cyclin-dependent kinases substrate in invasive ductal carcinoma of the breast.13

Citation

Dessen P

NUCKS1 (nuclear casein kinase and cyclin dependent kinase substrate 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-07-01

Online version: http://atlasgeneticsoncology.org/gene/51557/nucks1