OSBPL9 (oxysterol binding protein like 9)

2014-11-01  

Identity

HGNC
LOCATION
1p32.3
LOCUSID
ALIAS
ORP-9,ORP9
FUSION GENES

Other Information

Locus ID:

NCBI: 114883
MIM: 606737
HGNC: 16386
Ensembl: ENSG00000117859

Variants:

dbSNP: 114883
ClinVar: 114883
TCGA: ENSG00000117859
COSMIC: OSBPL9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117859ENST00000361556Q96SU4
ENSG00000117859ENST00000371714Q96SU4
ENSG00000117859ENST00000428468Q96SU4
ENSG00000117859ENST00000435274G8JLK0
ENSG00000117859ENST00000447887Q96SU4
ENSG00000117859ENST00000453295Q96SU4
ENSG00000117859ENST00000462759Q96SU4
ENSG00000117859ENST00000481937E9PKX6
ENSG00000117859ENST00000486942Q96SU4
ENSG00000117859ENST00000489990H0YE19
ENSG00000117859ENST00000495776H0YE93
ENSG00000117859ENST00000526917E9PK98
ENSG00000117859ENST00000527631E9PLH0
ENSG00000117859ENST00000528603H0YCW0
ENSG00000117859ENST00000531061H0YDB5
ENSG00000117859ENST00000531828Q96SU4
ENSG00000117859ENST00000532975E9PNR1
ENSG00000117859ENST00000533884E9PK98
ENSG00000117859ENST00000534040E9PJ80
ENSG00000117859ENST00000625138A0A096LPC8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Bile acid and bile salt metabolismREACTOMER-HSA-194068
Synthesis of bile acids and bile saltsREACTOMER-HSA-192105

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193770672009MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages.93
194133302009Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.85
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
195543022009OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
169622872007Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation.10
205999562010OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface.7
252550262014Characterization of the sterol and phosphatidylinositol 4-phosphate binding properties of Golgi-associated OSBP-related protein 9 (ORP9).5
241906122014Association of oxysterol binding protein-related protein 9 polymorphism with cerebral infarction in Hunan Han population.1

Citation

Dessen P

OSBPL9 (oxysterol binding protein like 9)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71556/osbpl9