OSMR (oncostatin M receptor)

2003-12-01  

Identity

HGNC
LOCATION
5p13.1
LOCUSID
ALIAS
IL-31R-beta,IL-31RB,OSMRB,OSMRbeta,PLCA1
FUSION GENES

Other Information

Locus ID:

NCBI: 9180
MIM: 601743
HGNC: 8507
Ensembl: ENSG00000145623

Variants:

dbSNP: 9180
ClinVar: 9180
TCGA: ENSG00000145623
COSMIC: OSMR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145623ENST00000274276Q99650
ENSG00000145623ENST00000502536Q99650
ENSG00000145623ENST00000508882H0Y8W9
ENSG00000145623ENST00000509237H0YAD1
ENSG00000145623ENST00000513831H0Y9E3

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 family signalingREACTOMER-HSA-6783589
IL-6-type cytokine receptor ligand interactionsREACTOMER-HSA-6788467

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
283683832017Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.94
202055912010Host determinants of HIV-1 control in African Americans.80
261987702015Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology.40
196620902009Promoter DNA methylation of oncostatin m receptor-beta as a novel diagnostic and therapeutic marker in colon cancer.29
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
198345352009Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.27
181798862008Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis.22
120618402002Coexpression of oncostatin M and its receptors and evidence for STAT3 activation in human ovarian carcinomas.17
219529232011Overexpression of the oncostatin M receptor in cervical squamous cell carcinoma cells is associated with a pro-angiogenic phenotype and increased cell motility and invasiveness.17
186413562008Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation.14

Citation

Dessen P

OSMR (oncostatin M receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41616/osmr