P2RX1 (purinergic receptor P2X 1)

2011-02-01  

Identity

HGNC
LOCATION
17p13.2
LOCUSID
ALIAS
P2X1
FUSION GENES

Other Information

Locus ID:

NCBI: 5023
MIM: 600845
HGNC: 8533
Ensembl: ENSG00000108405

Variants:

dbSNP: 5023
ClinVar: 5023
TCGA: ENSG00000108405
COSMIC: P2RX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108405ENST00000225538P51575
ENSG00000108405ENST00000571637I3L3H3

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Platelet activationKEGGhsa04611
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Elevation of cytosolic Ca2+ levelsREACTOMER-HSA-139853
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
200682322010Basal release of ATP: an autocrine-paracrine mechanism for cell regulation.113
206602882010Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse.113
191180952009ATP-induced vasodilation and purinergic receptors in the human leg: roles of nitric oxide, prostaglandins, and adenosine.45
146991682004ATP binding at human P2X1 receptors. Contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists.43
196359232009P2X1 ion channels promote neutrophil chemotaxis through Rho kinase activation.36
160065612005Disruption of lipid rafts inhibits P2X1 receptor-mediated currents and arterial vasoconstriction.33
195526912009Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells.32
223930102012Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel.32
125219922003Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotype.30
216900892011Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gating.24

Citation

Dessen P

P2RX1 (purinergic receptor P2X 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52052/p2rx1