P2RX5 (purinergic receptor P2X 5)

2007-02-01 Affiliation

Identity

HGNC

P2RX5

LOCATION

17p13.2

LOCUSID

5026

ALIAS

LRH-1,P2X5,P2X5R

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5026
MIM: 602836
HGNC: 8536
Ensembl: ENSG00000083454

Variants:

dbSNP: 5026
ClinVar: 5026
TCGA: ENSG00000083454
COSMIC: P2RX5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000083454	ENST00000225328	Q93086
ENSG00000083454	ENST00000345901	Q93086
ENSG00000083454	ENST00000547178	Q93086
ENSG00000083454	ENST00000551178	Q93086
ENSG00000083454	ENST00000552050	B4DEG2
ENSG00000083454	ENST00000552276	K7EQ78
ENSG00000083454	ENST00000552456	H0YHT9
ENSG00000083454	ENST00000552723	H0YII8

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Hemostasis	REACTOME	R-HSA-109582
Platelet homeostasis	REACTOME	R-HSA-418346
Platelet calcium homeostasis	REACTOME	R-HSA-418360
Elevation of cytosolic Ca2+ levels	REACTOME	R-HSA-139853

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
21092862	2010	Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels.	75
25080478	2014	ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.	54
16322791	2005	A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia.	47
12880424	2003	Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells.	35
12787128	2003	Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.	29
17001079	2006	P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate.	24
19074734	2009	Myeloid leukemic progenitor cells can be specifically targeted by minor histocompatibility antigen LRH-1-reactive cytotoxic T cells.	13
20223879	2010	Genetic and functional analysis of human P2X5 reveals a distinct pattern of exon 10 polymorphism with predominant expression of the nonfunctional receptor isoform.	13
24868547	2014	Correlation between urothelial differentiation and sensory proteins P2X3, P2X5, TRPV1, and TRPV4 in normal urothelium and papillary carcinoma of human bladder.	6
18719914	2009	Aberrant expression of the hematopoietic-restricted minor histocompatibility antigen LRH-1 on solid tumors results in efficient cytotoxic T cell-mediated lysis.	4

Citation

Dessen P

P2RX5 (purinergic receptor P2X 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46407/p2rx5