P2RY6 (pyrimidinergic receptor P2Y6)

2007-02-01  

Identity

HGNC
LOCATION
11q13.4
LOCUSID
ALIAS
P2Y6
FUSION GENES

Other Information

Locus ID:

NCBI: 5031
MIM: 602451
HGNC: 8543
Ensembl: ENSG00000171631

Variants:

dbSNP: 5031
ClinVar: 5031
TCGA: ENSG00000171631
COSMIC: P2RY6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171631ENST00000349767Q15077
ENSG00000171631ENST00000349767A0A024R5I9
ENSG00000171631ENST00000393590Q15077
ENSG00000171631ENST00000393590A0A024R5I9
ENSG00000171631ENST00000393591Q15077
ENSG00000171631ENST00000393591A0A024R5I9
ENSG00000171631ENST00000393592Q15077
ENSG00000171631ENST00000393592A0A024R5I9
ENSG00000171631ENST00000535931F5GYF3
ENSG00000171631ENST00000536225F5H7H9
ENSG00000171631ENST00000538328Q15077
ENSG00000171631ENST00000538328A0A024R5I9
ENSG00000171631ENST00000540124Q15077
ENSG00000171631ENST00000540124A0A024R5I9
ENSG00000171631ENST00000540342Q15077
ENSG00000171631ENST00000540342A0A024R5I9
ENSG00000171631ENST00000542092Q15077
ENSG00000171631ENST00000542092A0A024R5I9
ENSG00000171631ENST00000544437F5GX90
ENSG00000171631ENST00000618468Q15077
ENSG00000171631ENST00000618468A0A024R5I9

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
P2Y receptorsREACTOMER-HSA-417957
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
87001271996Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor.91
190088572008P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
116906422001Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.41
124646202003Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation.41
182504782008Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP.40
163224722006Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway.38
211731182011Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation.37
126919582003ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells.30
197350762009Concomitant activation of P2Y(2) and P2Y(6) receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion.29

Citation

Dessen P

P2RY6 (pyrimidinergic receptor P2Y6)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46309/p2ry6