PDGFD (platelet derived growth factor D)

2007-02-01  

Identity

HGNC
LOCATION
11q22.3
LOCUSID
ALIAS
IEGF,MSTP036,SCDGF-B,SCDGFB
FUSION GENES

Other Information

Locus ID:

NCBI: 80310
MIM: 609673
HGNC: 30620
Ensembl: ENSG00000170962

Variants:

dbSNP: 80310
ClinVar: 80310
TCGA: ENSG00000170962
COSMIC: PDGFD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170962ENST00000302251Q9GZP0
ENSG00000170962ENST00000393158Q9GZP0
ENSG00000170962ENST00000529268H0YD37

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Gap junctionKEGGko04540
Regulation of actin cytoskeletonKEGGko04810
Prostate cancerKEGGko05215
MelanomaKEGGko05218
Focal adhesionKEGGhsa04510
Gap junctionKEGGhsa04540
Regulation of actin cytoskeletonKEGGhsa04810
Prostate cancerKEGGhsa05215
MelanomaKEGGhsa05218
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
Signal TransductionREACTOMER-HSA-162582
Signaling by PDGFREACTOMER-HSA-186797
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
EGFR tyrosine kinase inhibitor resistanceKEGGko01521
EGFR tyrosine kinase inhibitor resistanceKEGGhsa01521

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195444442009miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells.135
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
184037542008Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells.66
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
253919642014Radial glia require PDGFD-PDGFRβ signalling in human but not mouse neocortex.57
210987082010A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancer.50
235052192013Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma.45
152717962004PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis.44
159880362005Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells.36
241585612013Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway.31

Citation

Dessen P

PDGFD (platelet derived growth factor D)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46596/pdgfd