PEBP4 (phosphatidylethanolamine binding protein 4)

2007-02-01  

Identity

HGNC
LOCATION
8p21.3
LOCUSID
ALIAS
CORK-1,CORK1,GWTM1933,HEL-S-300,PEBP-4,PRO4408,hPEBP4
FUSION GENES

Other Information

Locus ID:

NCBI: 157310
MIM: 612473
HGNC: 28319
Ensembl: ENSG00000134020

Variants:

dbSNP: 157310
ClinVar: 157310
TCGA: ENSG00000134020
COSMIC: PEBP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134020ENST00000256404Q96S96
ENSG00000134020ENST00000522278E5RIK3

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447197Attention Deficit Disorder with HyperactivityDiseaseClinicalAnnotationassociatedPD29382897
PA450464methylphenidateChemicalClinicalAnnotationassociatedPD29382897

References

Pubmed IDYearTitleCitations
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
257212112015miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung adenocarcinoma cells.26
153028872004A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen-activated protein kinase pathway activation and phosphatidylethanolamine externalization.19
242762462014Phosphatidylethanolamine-binding protein 4 is associated with breast cancer metastasis through Src-mediated Akt tyrosine phosphorylation.16
168652372006Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways.13
250389152014Downregulation of PEBP4, a target of miR-34a, sensitizes drug-resistant lung cancer cells.13
191973392009Regulation of human myoblast differentiation by PEBP4.10
228018812013hPEBP4 as a predictive marker for the pathological response of rectal cancer to preoperative radiotherapy.8

Citation

Dessen P

PEBP4 (phosphatidylethanolamine binding protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46027/pebp4