PGAM1 (phosphoglycerate mutase 1)

2007-04-01  

Identity

HGNC
LOCATION
10q24.1
LOCUSID
ALIAS
HEL-S-35,PGAM-B,PGAMA
FUSION GENES

Other Information

Locus ID:

NCBI: 5223
MIM: 172250
HGNC: 8888
Ensembl: ENSG00000171314

Variants:

dbSNP: 5223
ClinVar: 5223
TCGA: ENSG00000171314
COSMIC: PGAM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171314ENST00000334828P18669
ENSG00000171314ENST00000334828Q6FHU2

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Glycine, serine and threonine metabolismKEGGko00260
Glycolysis / GluconeogenesisKEGGhsa00010
Glycine, serine and threonine metabolismKEGGhsa00260
Metabolic pathwaysKEGGhsa01100
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGhsa_M00001
Glycolysis, core module involving three-carbon compoundsKEGGhsa_M00002
Gluconeogenesis, oxaloacetate => fructose-6PKEGGhsa_M00003
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGM00001
Glycolysis, core module involving three-carbon compoundsKEGGM00002
Gluconeogenesis, oxaloacetate => fructose-6PKEGGM00003
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GlycolysisREACTOMER-HSA-70171
GluconeogenesisREACTOMER-HSA-70263
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
208472632010Evidence for an alternative glycolytic pathway in rapidly proliferating cells.253
231535332012Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.114
221570072012Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation.53
204031812010Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma.43
204710302010Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.42
196860462010Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer's disease.40
194059532009Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation.38
236532022013Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation.25
279919222017Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity.19
281229572017Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells.12

Citation

Dessen P

PGAM1 (phosphoglycerate mutase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46705/pgam1