PHF5A (PHD finger protein 5A)

2019-08-01  

Identity

HGNC
PHF5A
LOCATION
22q13.2
LOCUSID
84844
ALIAS
INI,Rds3,SAP14b,SF3B7,SF3b14b,bK223H9.2

Other Information

Locus ID:

NCBI: 84844
MIM: 617846
HGNC: 18000
Ensembl: ENSG00000100410

Variants:

dbSNP: 84844
ClinVar: 84844
TCGA: ENSG00000100410
COSMIC: PHF5A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100410ENST00000216252Q7RTV0
ENSG00000100410ENST00000216252A0A024R1U2

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, U2-snRNPKEGGhsa_M00352
Spliceosome, U2-snRNPKEGGM00352
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
236518572013Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A.60
285413002017Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.25
262444962015An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses.13
120545432002Identification and characterization of a novel murine multigene family containing a PHD-finger-like motif.9
297000042018PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression.9
295667132018PHD-finger domain protein 5A functions as a novel oncoprotein in lung adenocarcinoma.3
310549742019Acetylation of PHF5A Modulates Stress Responses and Colorectal Carcinogenesis through Alternative Splicing-Mediated Upregulation of KDM3A.3
309323582019PHD finger protein 5A promoted lung adenocarcinoma progression via alternative splicing.2
307668802019Knockdown of PHF5A Inhibits Migration and Invasion of HCC Cells via Downregulating NF-κB Signaling.0

Citation

Dessen P

PHF5A (PHD finger protein 5A)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58140/phf5a