PID1 (phosphotyrosine interaction domain containing 1)

2009-05-01  

Identity

HGNC
PID1
LOCATION
2q36.3
LOCUSID
55022
ALIAS
HMFN2073,NYGGF4,P-CLI1,PCLI1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55022
MIM: 612930
HGNC: 26084
Ensembl: ENSG00000153823

Variants:

dbSNP: 55022
ClinVar: 55022
TCGA: ENSG00000153823
COSMIC: PID1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153823ENST00000354069Q7Z2X4
ENSG00000153823ENST00000392054Q7Z2X4
ENSG00000153823ENST00000392055Q7Z2X4
ENSG00000153823ENST00000409462Q7Z2X4
ENSG00000153823ENST00000534952F5H314

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
200108352010Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.251
168156472006Identification and characterization of NYGGF4, a novel gene containing a phosphotyrosine-binding (PTB) domain that stimulates 3T3-L1 preadipocytes proliferation.12
190792912009Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt.12
171242472007Identification of the ligands of protein interaction domains through a functional approach.10
243007872014PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.9
232749132013Overexpression of TFAM protects 3T3-L1 adipocytes from NYGGF4 (PID1) overexpression-induced insulin resistance and mitochondrial dysfunction.5
201659042010Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes.4
301002442018The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins.3
198499472009[Effects of NYGGF4 gene over-expression on the insulin sensitivity and secretory function of adipocytes].1
222846332012NYGGF4 as a new therapeutic target for obesity-associated insulin resistance.1

Citation

Dessen P

PID1 (phosphotyrosine interaction domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50893/pid1