PLEKHO1 (pleckstrin homology domain containing O1)

2007-12-01  

Identity

HGNC
LOCATION
1q21.2
LOCUSID
ALIAS
CKIP-1,CKIP1,JBP,OC120
FUSION GENES

Other Information

Locus ID:

NCBI: 51177
MIM: 608335
HGNC: 24310
Ensembl: ENSG00000023902

Variants:

dbSNP: 51177
ClinVar: 51177
TCGA: ENSG00000023902
COSMIC: PLEKHO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000023902ENST00000369124Q53GL0
ENSG00000023902ENST00000369126Q5T4P9

Expression (GTEx)

0
50
100
150
200
250
300

References

Pubmed IDYearTitleCitations
158314582005The pleckstrin homology domain-containing protein CKIP-1 is involved in regulation of cell morphology and the actin cytoskeleton and interaction with actin capping protein.28
169878102006The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein.24
157063512005Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis.21
179428962007Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo.20
171971582007The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling.18
152540372004The Pleckstrin homology domain of CK2 interacting protein-1 is required for interactions and recruitment of protein kinase CK2 to the plasma membrane.17
163253752006CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM.12
163253752006CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM.12
228782162013CKIP-1: a scaffold protein and potential therapeutic target integrating multiple signaling pathways and physiological functions.11
239957902014CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation.11

Citation

Dessen P

PLEKHO1 (pleckstrin homology domain containing O1)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49933/plekho1