PLIN3 (perilipin 3)

2004-11-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
M6PRBP1,PP17,TIP47
FUSION GENES

Other Information

Locus ID:

NCBI: 10226
MIM: 602702
HGNC: 16893
Ensembl: ENSG00000105355

Variants:

dbSNP: 10226
ClinVar: 10226
TCGA: ENSG00000105355
COSMIC: PLIN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105355ENST00000221957O60664
ENSG00000105355ENST00000585479O60664
ENSG00000105355ENST00000585479A0A140VJN8
ENSG00000105355ENST00000587462K7EJD0
ENSG00000105355ENST00000589034K7EL96
ENSG00000105355ENST00000589163K7ERZ3
ENSG00000105355ENST00000589494K7ER39
ENSG00000105355ENST00000592528O60664

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
120771422002Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium.105
194512732009TIP47 functions in the biogenesis of lipid droplets.85
170031322006Tail-interacting protein TIP47 is a connector between Gag and Env and is required for Env incorporation into HIV-1 virions.81
183933902008Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis.78
154569052004Rab9 GTPase regulates late endosome size and requires effector interaction for its stability.65
127680122003Targeting of the human immunodeficiency virus type 1 envelope to the trans-Golgi network through binding to TIP47 is required for env incorporation into virions and infectivity.57
167698182006TIP47 is a key effector for Rab9 localization.44
235930072013Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein.40
233542852013TIP47 plays a crucial role in the life cycle of hepatitis C virus.29
194009542009Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis.27

Citation

Dessen P

PLIN3 (perilipin 3)

Atlas Genet Cytogenet Oncol Haematol. 2004-11-01

Online version: http://atlasgeneticsoncology.org/gene/42938/plin3