PNOC (prepronociceptin)

2014-06-01  

Identity

HGNC
PNOC
LOCATION
8p21.1
LOCUSID
5368
ALIAS
N/OFQ,NOP,OFQ,PPNOC,ppN/OFQ
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5368
MIM: 601459
HGNC: 9163
Ensembl: ENSG00000168081

Variants:

dbSNP: 5368
ClinVar: 5368
TCGA: ENSG00000168081
COSMIC: PNOC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168081ENST00000301908Q13519
ENSG00000168081ENST00000518479E7EVP0
ENSG00000168081ENST00000522209Q13519

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
129501772003Human neutrophils as a source of nociceptin: a novel link between pain and inflammation.21
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
179107402008Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence.16
179107402008Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence.16
195010742009Expression of pronociceptin and its receptor is downregulated in the brain of human alcoholics.12
267910552016Neonatal abstinence syndrome: Pharmacologic strategies for the mother and infant.11
262334862015Variations in opioid receptor genes in neonatal abstinence syndrome.9
256777752015Nociceptin/orphanin FQ-NOP receptor system in inflammatory and immune-mediated diseases.8

Citation

Dessen P

PNOC (prepronociceptin)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53968/pnoc