POLL (DNA polymerase lambda)

2004-04-01  

Identity

HGNC
LOCATION
10q24.32
LOCUSID
ALIAS
BETAN,POLKAPPA

Other Information

Locus ID:

NCBI: 27343
MIM: 606343
HGNC: 9184
Ensembl: ENSG00000166169

Variants:

dbSNP: 27343
ClinVar: 27343
TCGA: ENSG00000166169
COSMIC: POLL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166169ENST00000299206Q9UGP5
ENSG00000166169ENST00000339310Q5JQP4
ENSG00000166169ENST00000370162Q9UGP5
ENSG00000166169ENST00000370168Q9HBN3
ENSG00000166169ENST00000370169Q9UGP5
ENSG00000166169ENST00000370172Q5JQP8
ENSG00000166169ENST00000413344Q5JQP1
ENSG00000166169ENST00000415897Q5JQP2
ENSG00000166169ENST00000426919Q5JQN9
ENSG00000166169ENST00000429502Q5JQP3
ENSG00000166169ENST00000430045Q5JQP0
ENSG00000166169ENST00000454524Q5JQP7
ENSG00000166169ENST00000628479Q9UGP5

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
Non-homologous end-joiningKEGGko03450
Base excision repairKEGGhsa03410
Non-homologous end-joiningKEGGhsa03450
BER complexKEGGhsa_M00296
BER complexKEGGM00296
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Nonhomologous End-Joining (NHEJ)REACTOMER-HSA-5693571

References

Pubmed IDYearTitleCitations
145617662004Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts.82
156086522005A closed conformation for the Pol lambda catalytic cycle.76
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
118214172002DNA polymerase lambda, a novel DNA repair enzyme in human cells.52
198201682009An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda.45
128296982003The frameshift infidelity of human DNA polymerase lambda. Implications for function.37
156653102005Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.36
208058752010DNA polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts.36
201642412010Analysis of specialized DNA polymerases expression in human gliomas: association with prognostic significance.35
123682912002Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis.34

Citation

Dessen P

POLL (DNA polymerase lambda)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/41778/poll