PON2 (paraoxonase 2)

2010-05-01  

Identity

HGNC
LOCATION
7q21.3
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 5445
MIM: 602447
HGNC: 9205
Ensembl: ENSG00000105854

Variants:

dbSNP: 5445
ClinVar: 5445
TCGA: ENSG00000105854
COSMIC: PON2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105854ENST00000222572Q15165
ENSG00000105854ENST00000433091Q15165
ENSG00000105854ENST00000446142A0A2Q2SAK4
ENSG00000105854ENST00000455123G3XAK4
ENSG00000105854ENST00000469926A0A0J9YXU7
ENSG00000105854ENST00000478801A0A0J9YVW3
ENSG00000105854ENST00000483292A0A0J9YYJ1
ENSG00000105854ENST00000490778A0A0J9YYF3
ENSG00000105854ENST00000491069A0A0J9YXM1
ENSG00000105854ENST00000493290A0A0J9YYF0
ENSG00000105854ENST00000632034A0A0J9YXM1
ENSG00000105854ENST00000633192A0A0J9YXF2
ENSG00000105854ENST00000633531Q15165

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of 5-eicosatetraenoic acidsREACTOMER-HSA-2142688

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
157724232005Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities.167
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
174041542007Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation.75
150013262004Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies.69
209341782011The three-gene paraoxonase family: physiologic roles, actions and regulation.63
195873572009A systematic meta-analysis of genetic association studies for diabetic retinopathy.57
168913032006Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2.47
205304812010One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity.47
183470342008Dominant role of paraoxonases in inactivation of the Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl)-L-homoserine lactone.38
150391252004Genotypes and haplotypes predisposing to myocardial infarction: a multilocus case-control study.33

Citation

Dessen P

PON2 (paraoxonase 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51467/pon2