POU2F3 (POU class 2 homeobox 3)

2007-02-01  

Identity

HGNC
POU2F3
LOCATION
11q23.3
LOCUSID
25833
ALIAS
Epoc-1,OCT-11,OCT11,OTF-11,PLA-1,PLA1,Skn-1a
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25833
MIM: 607394
HGNC: 19864
Ensembl: ENSG00000137709

Variants:

dbSNP: 25833
ClinVar: 25833
TCGA: ENSG00000137709
COSMIC: POU2F3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137709ENST00000260264Q9UKI9
ENSG00000137709ENST00000532663H0YLC5
ENSG00000137709ENST00000533620E9PIN6
ENSG00000137709ENST00000543440Q9UKI9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
299458882018POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer.20
208887992010Skn-1a/Oct-11 and ΔNp63α exert antagonizing effects on human keratin expression.19
244289372014Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium.16
126241092003Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation.11
166072782006Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer.11
171950132007Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation.5
251781052015The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3.5
210749762010Relation between the expression levels of the POU transcription factors Skn-1a and Skn-1n and keratinocyte differentiation.4
184794612008Transcription factor human Skn-1a enhances replication of human papillomavirus DNA through the direct binding to two sites near the viral replication origin.3

Citation

Dessen P

POU2F3 (POU class 2 homeobox 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43760/pou2f3